The greatest impact it made on me was the realisation that only one out of those four devs were truly happy, namely the guy with that (sparta?) cat and a wife. The movie gave me the impression that full time indie development breaks people, until nothing but a weeping wreck is left. Even though their games were successful, they were left with nothing but emptiness and a story. A story that cannot be told because it is incomprehensible to most. It conveys the message that indie development is not worth doing. I suppose that's somewhat true if you look at the number-of-devs to successful-devs ratio.
But then again, there are some valid points concerning their personality. Perhaps they don't know how to handle success.