Personally I started out on the C64 and then on the Amiga with software like DeluxePaint. There was hardly any choice than really doing pixel by pixel. Except for tools doing circles and stuff.
I've noticed that this has influenced my way of drawing 2D art quite a lot. I still prefer doing stuff as much as possible pixel by pixel instead of using fancy plugins (EyeCandy etc) and filters.
I think the best is to using the available tools without overdoing it, and then combine that with the total control of manipulating pixel by pixel.
I guess that if you use a mouse or a pen/pad will affect the techniques used too. However, a pen might be useful for sketches but hardly any details.
Agree/disagree with my thoughts?