I typically see this as trying to find niches that game giants or other popular games do not cover.
Like don't build an RTS that has only a subset of features as Starcraft, but instead focus it around things they don't have, such as underwater, and underground uses, or long range rockets, or AI based robot attacks, where you set a mission, but then lose control of the robot until it completes its task and returns.
But the general idea is to make sure that you'll be able to market your game by focusing on these differences, instead of advertising things that someone else already does.
That is my take on it, what else is there? As a David, what are your concerns with Goliath game giants as competition? How do you deal with that?
I guess this could be more generalized as suggestions on how to make a David Survive and Thrive?
Edited by Dan Violet Sagmiller, 13 February 2013 - 12:08 PM.