The popup is a pain in the neck. Fine display it when first visit the site or say login but every page that I open during a session, really?
I will not disable my ad-block as I use it for a number of reasons including saving bandwidth and security as ad-brokers have been hacked in the past to serve up payloads even on very high profile sites.
I, on the other hand, have whitelisted the site, but right now it's probably a 50/50 toss-up between which is more annoying and intrusive: the nagging pop-up or the adverts.
Either way it's definitely impacted my usage of the site. Which is a pity.