Absolutely not. Nothing worse than disturbing immersion, in my book. Though there may be a way to utilize this without disturbing immersion depending on the specific system, I suppose.
Rearrangment of skills on hotbar for a small period of time
This one I like a lot. Secret of Mana had confusion spells that would reverse your directional control when hit by them. At first it was crippling, but you could adapt and navigate just fine during that period after you were hit by the spell a few times. I like this idea because it doesn't ruin immersion, but it forces the player to adapt to small shifts in the game. Expands the mind.
Inversing controls (move left by pressing right)for a small period of time
Generally I think it's a great idea. If you make it part of the gameplay then the player shouldn't feel cheated; it's just another obstacle/challenge the player must overcome to excell at the game.