Tic Tac Toe wouldn't work properly as a 3 in a row on a 5x5 grid.
The first will always win if they place a piece in the center or the middle ring.
No matter where the second person goes the first person will be able to place a piece on the center/middle ring, the second person has two options to block, and the first person wins on the third go.
A 4 in a row on a 5x5 grid may be a little harder but the first person will always be in the lead as the second person will have to block every single turn instead of trying to score a 4 in a row.
5 in a row, will end in more stalemates as there are more places for each other to block and only 12 ways to win.