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I don't know if that counts as a TD. A TD includes towers and enemies in a lane going towards a point -- this would be more or a Tower Wars. Instead of turn based, maybe real-time? With creep cards that could travel one of the lanes/a single lane and fight oncoming monsters, with tower cards that can be placed beside the lane(s) and fire at incoming enemies. Buffs could include stuff like faster card drawing (as in, twice/trice per "tick"), making the enemy throw away one of his cards etc.
In any case, do explore the idea, it seems interesting