Hello everyone, I hope this is the right place to post this question. Hopefully some of you have played the SNES game "Shadowrun" which looks like this: http://i.imgur.com/4CjnHgR.jpg
When I say "best way" I mean, is it more feasible to make a game that looks like this in a 2D game engine like GameMaker or a 3D one like Unity?
Isometric games like that are often easier to make in 2D.
They also require a ton of pixel art and some skilled artists.
You can use any of them, I would go for the one I am more experienced or the one I have easier access to assets.
By the way, if you are going to make the art yourself, this link can be pretty handy:
http://2dgameartforprogrammers.blogspot.com.br/2012/02/building-isometric-art-in-vectors-step.html
Considering the "new" ShadowRun is being written in Moai, I would have to recommend Moai. 
Moai is a great little cross platform 2D library with Isometric graphics built in. It's a bit tricky to come to terms with, as the documentation is.... lacking, but I've done some tutorials that can get you started. Moai is scripted in Lua, but is powered by an open sourced C++ engine, which has some remarkably clean code behind it. It runs on a number of platforms, pretty much all the ones you would care about ( sorry Windows Phone.... )
Thank you everyone for replying, I will take all of your advice and do it 2D instead, thank you for the links Serapth and KnolanCross.
