Hi. It does make it less obvious.
Is using tiles a requirement? that is, do you plan on having gameplay on that map screen, with characters walking around etc.?
Because you would most likely feel more freedom if you treated it like a freehand, digital painting.
The following are freehand drawn game maps:
http://i40.tinypic.com/2iglkir.png
http://images2.wikia.nocookie.net/__cb20130209111915/ragnarok8812/images/7/7a/RO_world_map.jpg
http://mmohuts.com/wp-content/gallery/angels-online-overview/angels-online-world-map.jpg?ec9f9b
http://everquest.allakhazam.com/gallery/ingamemaps/antonica4.jpg