I can only speak from the gamer's perspective, so I hope this will be helpful.
Regardless of the amount of jumping, I'd rather have jump on Space and interact in E, for 2 reasons:
1) Space being jump is in sooo many games that it's basically embedded into gamer's subconscious, and changing that will just throw everyone off balance
2) E is basically under the finger and more... preferred for that usage (again, vast amount of other games have influenced this).
Other than the control assignment you wrote, on the keyboard... there isn't actually any. Reason for that I believe is the button location - you have WASD buttons, standardized in almost every 3D game for movement, under your ring, middle and index finger, easily accessible Q, E, R, F, V, C, X and Y with those same fingers, pretty big Space button under thumb, and two bigger buttons - L Shift and L Ctrl - under little finger.
Sure, you can move that setup to the, for example, RDFG for movement but that will only confuse everyone.
Before (iirc about 10 years ago), common movement setup was arrow buttons (and now in the games which don't require many buttons) because arrows... well... symbolize movement. However, there aren't any other buttons set up near them so hand has to jump on the alphanumeric part of the keyboard for other buttons. Only button that's conveniently placed is the R Ctrl for little finger.
However, there is one other setup that I have on my mind... I don't know how the left handed people use PC, but probably having left-handed setup based on numeric part of keyboard (8456 for movement, 0 for jump, 7 for interact, 9 for autorun etc.) would be at least appreciated.