As a 3d character designer I will advise against it.
Not because it I think it is wrong to use modeling software like Makehuman, I myself have it installed and have followed there progress for years, but modeling a full human is the highest form of 3d modeling and it sharpens all of your modeling skills.
Making any 3d model takes a lot of planing, if you want the Iris of the eye to retract or a person's mouth to dimple at the end, then you will have to model it that way.
These small things along with your idea of a character while you model it is what brings them to life.
Makehuman's topology and edge flow has taken leaps from where thy started, but it will not suit all of your character needs.
I have started to make base meshes using Zbrush. I found it much easier to sculpt the base rather than modeling it. Then converting it to low poly by retopo.