Yeah, I know makehuman can generate a realistic human on some points, but on others it can't yet without some tweaking. That would go for both software, but there is less tweaking in Quidam needed.
For example, you know realism is all about accuracy, but there are different criteria in several areas that needs to be met for achieving realism. One issue where Makehuman lacks is in the actual topology of their base meshes. They have very dense meshes, but the topology of the Quidam studio base meshes are much better for animating. Also, the weighting of the bones when exporting from makehuman into Blender are not accurate enough, so you have to tweak it there. Although, quidam studio has its rig issues as well (strangely rotated and scaled bones when exporting in the collada format).
Now, recently someone created some amazing textures for the makehuman models. Those textures are great, but that is a result of good texturing, not the result of a good model.
Also, as I have seen in many 3d character generation software, you really have to tweak the model to get natural proportions. Quidam Studio actually has a separate proportion menu.
Also, texturing can be done right in Quidam studio, and it automatically tiles the texture you are painting with so that it blends smoothly. I would prefer software for such a task over a software that was built to do only that (accept zbrush).
There are other things also.